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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RAPGEF4
All Species:
26.36
Human Site:
T499
Identified Species:
48.33
UniProt:
Q8WZA2
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8WZA2
NP_001093867.1
1011
115522
T499
S
Q
P
Q
Q
K
Y
T
V
M
S
G
T
P
E
Chimpanzee
Pan troglodytes
XP_522596
881
99309
G407
F
H
V
E
P
A
G
G
S
E
Q
E
R
S
T
Rhesus Macaque
Macaca mulatta
XP_001086678
1077
122312
T565
S
Q
P
Q
Q
K
Y
T
V
M
S
G
T
P
E
Dog
Lupus familis
XP_545524
1011
115217
T499
S
Q
P
Q
Q
K
Y
T
V
M
S
G
T
P
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQZ6
1011
115473
T499
S
Q
P
Q
Q
K
Y
T
V
M
S
G
T
P
E
Rat
Rattus norvegicus
Q9Z1C7
436
50098
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514742
1011
115505
T499
S
Q
P
Q
Q
K
Y
T
V
M
S
G
T
P
E
Chicken
Gallus gallus
XP_426579
1011
115518
I499
S
Q
P
Q
H
K
Y
I
V
M
S
G
T
P
E
Frog
Xenopus laevis
NP_001089076
890
102453
E416
P
S
E
V
N
E
P
E
K
A
T
Y
S
L
Q
Zebra Danio
Brachydanio rerio
XP_687578
1006
115354
T494
S
S
S
P
L
K
Y
T
V
M
S
G
T
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097202
998
112889
T481
Q
H
S
A
F
K
Y
T
V
M
S
G
T
P
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34578
1234
141798
S715
C
N
F
N
C
G
Y
S
V
M
A
G
K
A
E
Sea Urchin
Strong. purpuratus
XP_784278
676
77986
I202
E
D
F
L
L
T
H
I
V
F
M
P
S
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
44.3
90.8
97.8
N.A.
97.3
41.3
N.A.
93.9
92.1
45.4
78.6
N.A.
49
N.A.
31.6
39.6
Protein Similarity:
100
61
91.5
98.9
N.A.
98.6
42
N.A.
97.7
96.7
62.2
89.5
N.A.
67
N.A.
50
51.4
P-Site Identity:
100
0
100
100
N.A.
100
0
N.A.
100
86.6
0
73.3
N.A.
60
N.A.
33.3
6.6
P-Site Similarity:
100
6.6
100
100
N.A.
100
0
N.A.
100
86.6
26.6
73.3
N.A.
60
N.A.
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
0
0
8
8
0
0
8
8
% A
% Cys:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
8
8
0
8
0
8
0
8
0
8
0
8
62
% E
% Phe:
8
0
16
0
8
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
8
8
0
0
0
70
0
0
0
% G
% His:
0
16
0
0
8
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
62
0
0
8
0
0
0
8
0
8
% K
% Leu:
0
0
0
8
16
0
0
0
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
70
8
0
0
0
0
% M
% Asn:
0
8
0
8
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
0
47
8
8
0
8
0
0
0
0
8
0
62
0
% P
% Gln:
8
47
0
47
39
0
0
0
0
0
8
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
54
16
16
0
0
0
0
8
8
0
62
0
16
8
0
% S
% Thr:
0
0
0
0
0
8
0
54
0
0
8
0
62
0
8
% T
% Val:
0
0
8
8
0
0
0
0
77
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
70
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _